Abstract
ABSTRACT True anaphylaxis was produced in ovomucoid sensitized mice after a 20 day incubation period. The fatal anaphylaxis from a shock dose of egg albumin (I. P.) in normal, untreated and insulin treated diabetic, untreated and insulin treated glucose fed animals was compared. Fatal anaphylaxis did not occur in either diabetic or glucose fed mice unless insulin had been administered 1 hour before the shock dose. The inflammatory response to cotton pellet implantation was measured in normal, untreated and insulin treated diabetic, and glucose fed rats. Granulation tissue formation was significantly depressed by diabetes as well as glucose feeding, and was restored to control values in insulin treated diabetic animals. Thymic involution which was apparent in all diabetic rats did not occur in glucose fed rats. The anti-anaphylactic, anti-inflammatory and thymolytic effects of diabetes strongly suggests adrenal hyperactivity. However, the absence of thymolysis in glucose fed rats implies that glycaemia through some metabolic effect rather than adrenal hyperactivity alters the sensitivity to inflammatory responses.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
