Abstract
Necrotizing enterocolitis (NEC) is an intestinal disease with significant morbidity and mortality in the newborn infant. Animal models of NEC implicate hypoxia and hypothermia in causing ischemic intestinal injury. The pathogenesis of intestinal injury in low flow states may be mediated by O2 radicals. We hypothesized O2 radicals generated by the xanthine dehydrogenase (XD)/xanthine oxidase (XO) system augment injury and an XO inhibitor, allopurinol (AP) would decrease injury.
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