Effect of Allicin in Reducing the Cytotoxicity of Cyclophosphamide on Reproductive System of Wister Male Rats

Abstract

The aim of the present study is to investigate the positive role of Allicin in reducing the side effects induced by cyclophosphamide drug in reproductive system of male rats. In this experiment, fifty adult male Wister rats were used, about four month old, with average weight about (162.5±13gm). They were divided randomly into five equal groups (10 animals for each group) and drenched for 60 consecutive days as follows: The results of this study revealed significant differences (P ≤ 0.05) represented by increasing in concentration of testosterone, SSH and ICSH hormones in T1 group as compared with other groups, while there was a significant decrease in T2 group as compared with other groups. Also, there was a significant difference represented by increasing levels of these hormones in T3 and T4 groups as compared with T2 group ,and there was a significant difference in concentration of testosterone, SSH and ICSH between T3 and T4 groups represented by increasing the concentration of these hormones in T4 group as compared with T3 group. It is concluded that allicin has in dose of 50 mg/kg/B. W. both a preventive and a therapeutic role in ameliorating cyclophosphamide toxicity in adult Wister male rats. The use of allicin as a therapeutic agent showed more amelioration in cyclophosphamide toxicity than a preventive agent.