Abstract
Retinoids have proved to prevent carcinogenic transformation in head and neck premalignant lesions and to decrease the rate of secondary primary carcinoma in patients with head and neck cancer. Recent studies have demonstrated the efficacy of retinoic acid in inducing differentiation therapy of carcinoma. In the present study, all-trans-retinoic acid (ATRA) was tested for its anti-proliferative activity against human salivary adenoid cystic carcinoma cell (ACC-M) by means of clonogenic assay and MTT assay, as well as cell cycle analysis in vitro. The results showed that there was a decrease in the ratio of S phase cells after 72 hours of treatment, together with an increase in the ratio of G0 and G1 phase, indicating that ATRA could inhibit the proliferation of ACC-M cell in a dose- and time-dependent manner. Steve G. F. Shen
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