Abstract
SummaryThe role of acetylation of ribosomal proteins in the regulation of protein synthesis was investigated by examination of the effect of aldosterone injection into adrenalectomized rats on the in vivo incorporation of [3H] acetate into the ribosomal proteins of kidney cortex and medulla (outer and inner zones) separately. Incorporation of acetate into acetyl groups of the ribosomal proteins of adrenalectomized rats was highest in the cortex. Three and a half hours after aldosterone administration, acetate incorporation in the cortex was 60% lower and in the medullary zones 77–94% higher than in the saline injected controls. This decrease for the cortex, and a calculated 38% decrease for whole kidney, are negatively correlated with increased protein synthesis after hormone administration.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.