Abstract

Abstract: Effects of alcohol and heparin on aggregation of the recombinant tau have been studied. Alcohol at low concentrations induces tau polymerization distinguishably at room temperature and 37°C. The effect of heparin on tau's aggregation was cooperative with that of alcohol if both heparin and alcohol were added to tau solutions. It appears that the polymerization of tau might be correlated to the disorder of neuronal transportation of alcoholism.

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