Abstract
Abstract The relation between uptake of lead and the level in blood (PbB) is curvilinear, but it is not certain whether this is true for all levels of intake, or only when PbB exceeds some value. Volunteers have been exposed to enhanced air lead (PbA) and epidemiological studies of the relation between PbB and PbA have been made. From these, the slope of the curve of PbB vs PbA can be estimated. Tracer experiments using radioactive or stable isotopes of lead can be used to derive the contribution of PbA to PbB. Because the response is curvilinear, the fractional contribution of PbA to PbB is greater than the slope of the curve.
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