Effect of Agraz (Vaccinium meridionale Swartz) on High-Density Lipoprotein Function and Inflammation in Women with Metabolic Syndrome.

Catalina Marín-Echeverri,Christopher Blesso,Vitelbina Núñez-Rangel,Maria Fernández,Gelmy Ciro-Gómez,Jacqueline Barona-Acevedo,Yeisson Galvis-Pérez,Juan Aristizábal

doi:10.3390/antiox7120185

Catalina Marín-Echeverri, Christopher Blesso + Show 6 more

Open Access

https://doi.org/10.3390/antiox7120185

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Journal: Antioxidants	Publication Date: Dec 8, 2018
Citations: 16	License type: CC BY 4.0

Affiliation: University of Antioquia, University of Connecticut

Abstract

Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on human health. We evaluated the effects of agraz consumption as compared to placebo on HDL function and inflammation in women with MetS. Forty volunteers (25–60 years) were included in this double-blind crossover study. Women consumed agraz or placebo over 4 weeks; separated by a 4-week washout period. HDL function (apoliprotein-A1; paraoxonase 1 (PON1) activity; cholesterol efflux capacity), oxidative stress (myeloperoxidase (MPO), advanced oxidation protein products) and inflammatory markers (serum cytokines/chemokines and peripheral blood mononuclear cell nuclear factor-kB) were measured after each period. Compared to placebo, agraz consumption did not significantly change any of the biomarkers measured. Interestingly, only after agraz period there were significant positive correlations between PON1 activities and cholesterol efflux. Additionally, there were significant inverse correlations between changes in inflammatory markers and HDL function markers and positive correlations with oxidative markers. Although polyphenol-rich foods have been shown to be beneficial for certain conditions; polyphenol-rich agraz fruit consumption did not impact inflammation and HDL function in the current study of women with MetS.

Highlights

Metabolic syndrome (MetS) is a cluster of metabolic disorders shown to raise the risk of developing atherosclerotic cardiovascular diseases (CVDs) [1], which represent the leading cause of death worldwide [2]
The high-density lipoprotein (HDL)-c mean for these women was
We found a positive correlation between paraoxonase 1 (PON1) activity and cholesterol efflux after agraz consumption, but not after placebo consumption, suggesting a stronger link between these HDL markers with agraz consumption

Summary

Introduction

Metabolic syndrome (MetS) is a cluster of metabolic disorders shown to raise the risk of developing atherosclerotic cardiovascular diseases (CVDs) [1], which represent the leading cause of death worldwide [2]. This syndrome is associated with low-grade chronic inflammation characterized by increased C-reactive protein (CRP) [3], cytokines such as interleukin (IL)-6, tumor necrosis factor-α (TNF-α) [4], monocyte chemoattractant protein-1 (MCP-1) [5], and IL-8 [6], supporting the evidence that inflammation plays an important role in cardiovascular risk. Disappointing results with drug therapies aiming to increase HDL-c have been reported, as some studies have not shown to prevent future cardiovascular events with increases in HDL-c [10,11]. This information suggests that other aspects of HDL should be considered

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