Abstract
Hydrochlorothiazide tablets were prepared using acacia, starch, and polyvinylpyrrolidone as granulating agents. The tablets were evaluated at room temperature and at elevated temperatures relative to changes in hardness, disintegration, and dissolution. Acacia is an unsatisfactory granulating agent because the values of the hardness, disintegration, and dissolution times are increased with aging; starch and polyvinylpyrrolidone are acceptable granulating agents because the physical properties of the tablets are essentially unchanged with aging. The changes in the physical properties of the tablets after short-term storage at elevated temperatures correlated with the changes upon aging for 1 year at room temperature. Thus, for the formulations used in this study, changes occurring after short-term storage at 37, 50, and 80° could be used to predict changes in physical properties during the normal shelf-life of the tablets at room temperature.
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