Abstract
Age-correlated decrease in lymphocyte transformation in blood cultures treated with phytohemagglutinin (PHA) had been noted previously in a Marshallese population. In this same population, acetylation of nuclei in PHA-treated lymphocytes was measured at various times as a function of lymphocyte transformation and aging. Decreased acetylation of nuclei was associated with increasing age and roughly paralleled the decrease in lymphocyte transformation. Total acetate incorporation in nuclei during the first hour of culture was correlated with acetylation of histones, but by 20 hours acetylation of other nuclear material had also occurred.
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