Abstract
The present study was designed to examine the effect of aging on the neurotoxicity of theophylline in rats. Rats at one, three and six months of age were infused with intravenous theophylline (as aminophylline) at 1.03, 5.1 and 6.8 mg/mn respectively until onset of maximal seizures when theophylline concentrations were determined in serum, brain and cerebrospinal fluid (CSF). Theophylline concentrations in serum (both total and unbound) increased from one to six month old rats and were related to drug input rate and not to age of the rats. A similar increase was noted in brain concentrations, especially at the fastest infusion rate. Theophylline concentrations in CSF at onset of maximal seizures were not different in the three groups of rats. It is therefore concluded that moderate aging has a negligible effect on the neurotoxic response to theophylline in rats.
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