Abstract
The advent of newer therapies has significantly improved the outcomes in patients (pts) with refractory multiple myeloma (MM). However, the treatment of elderly pts remains challenging. Selinexor (SEL) is a novel, oral selective inhibitor of nuclear export (SINE) which forces nuclear retention and activation of tumor suppressor proteins. SEL plus low dose dexamethasone (SEL-DEX) induced an overall response rate (ORR) of 26.2% in pts with penta-exposed, triple-class refractory MM. Side effects were generally reversible without evidence of major organ toxicities.
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