Abstract
This study was conducted to investigate the histologic changes of kidney, urinary bladder, testis, seminal vesicle and prostate gland of rats of various ages (6,12 and 18 months old). Results illustrated variable changes of kidney represented by congestion of renal capillaries, acute tubular necrosis, shrinkage of glomerular tuft, degeneration in tubular epithelium of the 6,12 and 18 months old rats, the morphometric changes of the glomerular diameter decreases with advanced age. The lesions of urinary bladder characterized by hyperplasia of the epithelial lining, papillae into the lumen, hypertrophy of muscle fibers, desquamation of epithelium, cystitis in addition to thickening of the mucosa and hyalinization of muscle fibers of the 6,12 and 18 months old rats. The thickness of the bladder wall showed a significant changes increase at (P≤0.05) with age, while morphometric analysis did not show any age related changes in the bladder muscle thickness. In testis there were congestion of blood vessels, a spermia, degeneration of the spermatocytes and spermatozoa, thickening of interstitial and hyperplasia of leydig cells of the 6,12 and 18 months old rats. The wall thickness of Seminiferous tubule increases with age and basement membrane thickness and tubular diameter decreased with age. The seminal vesicle of the 6,12 and 18 months old rats revealed hyperplasia of glandular epithelium. Lesions of the prostate gland of 6,12 and 18 months old rats showed epithelial hyperplasia which extended as finger-like projections and presence of variable amounts of colloid substance.
Highlights
This study was conducted to investigate the histologic changes of kidney, urinary bladder, testis, seminal vesicle and prostate gland of rats of various ages (6,12 and 18 months old)
One of the most important risk factors in the development of aging is the changes in reproductive system which is closely related to changes in the urinary system .The aim of this study was to observe the histopathological changes in aging kidney, urinary bladder, testis, Materials and methods
Microscopic examination of sections prepared from the specimens of rat's kidney (6months old) revealed presence of congestion of renal capillaries, acute tubular necrosis and reduction or shrinkage of glomerular tuft ( Fig1) .Sections of the kidney of the 12 month old rats showed shrinkage of glomerular tuft and degeneration in tubular epithelium ( Fig 2)
Summary
This study was conducted to investigate the histologic changes of kidney, urinary bladder, testis, seminal vesicle and prostate gland of rats of various ages (6,12 and 18 months old). The experimental study included thirty albino rats which were divided into three groups of equality distributed (n =10), young adult (6 months old), adult (12 months old) and adult (18 months old) male rats that were obtained from the animal house in the College of Medicine, Mosul University. They were fed ad libitum and had free access to water. One way analysis of variance (ANOVA) was performed to test for significance followed by Duncan multiple range comparison tests for comparisons between the groups (P
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