Abstract
Abstract Background Cardiac troponins are the recommended markers for the detection of acute myocardial infarction (AMI). There is a controversy regarding their decision limits. In this study, our objective was to reveal the cut-off values of high-sensitive troponin T (hsTnT) for AMI diagnosis in our population and to examine the effect of age and gender on hsTnT cut-off values. Methods Patients who presented to the emergency department (ED) with chest pain were selected, and only those patients admitted during the first 3–6 h of symptom onset were included in the study. Results A total of 484 men and 182 women were included. A total of 355 (279 men/76 women) patients were diagnosed with AMI. The cut-off values of hsTnT were found to be 17 ng/L and 16 ng/L, for males and females, respectively. The cut-off values of hsTnT were detected to be significantly higher in men over 40 years of age (24 ng/L) than in men less than 40 years of age (10 ng/L). Conclusions The cut-off value for the hsTnT test for AMI was slightly lower in females than in males. The cut-off levels of hsTnT for the diagnosis of AMI were found to be significantly higher in men over 40 years of age than in men less than 40 years of age.
Highlights
Cardiovascular diseases and acute myocardial infarction (AMI) constitute up to 32% of all deaths worldwide [1]. Biomarkers are important tools in the diagnosis, treatment and prognosis of heart diseases [2,3,4]
The cut-off value for the high-sensitive troponin T (hsTnT) test for AMI was slightly lower in females than in males
The cut-off levels of hsTnT for the diagnosis of AMI were found to be significantly higher in men over 40 years of age than in men less than 40 years of age
Summary
Cardiovascular diseases and acute myocardial infarction (AMI) constitute up to 32% of all deaths worldwide [1]. Biomarkers are important tools in the diagnosis, treatment and prognosis of heart diseases [2,3,4]. Isiksacan et al.: Age and gender effect on troponin T cut-off reported that the usage of a standard cut-off value (14 ng/L) for the high-sensitive cardiac troponin T (hsTnT) assay may cause over-diagnosis of myocardial infarction, especially in elderly people and men [7]. Kimenai et al showed that the cut-off values for hsTnT and hsTnI were lower in women than in men (hsTnT: 12 vs 16 ng/L; hsTnI: 11 vs 20 ng/L) and increased with age [8] In their other study, they suggested a downward adjustment of hsTn thresholds in women to reduce the under-diagnosis of AMI in women [9]. Our objective was to reveal the cut-off values of high-sensitive troponin T (hsTnT) for AMI diagnosis in our population and to examine the effect of age and gender on hsTnT cut-off values. The cut-off values of hsTnT were detected to be significantly higher in men over 40 years of age (24 ng/L) than in men less than 40 years of age (10 ng/L)
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