Abstract
The effect of aflatoxin on the activities of 5 rat liver lysosomal enzymes (acid deoxyribonuclease, arylsulfatases A and B, β-glucuronidase, β-glucosidase and β-galactosidase) has been investigated in vivo and in vitro . Three hours after the administration of aflatoxin, activities of most of the enzymes increased significantly reaching maximal levels at 48 hr. The activity of acid DNase increased the most (276 per cent of the control level). At the same period (48 hr) the activity of the soluble lysosomal enzymes greatly increased. Aflatoxin had a labilizing effect on lysosomal membranes, causing the release of lysosomal enzymes into the supernatant. The data are discussed in connection with the biochemical mechanism of aflatoxin intoxication.
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Schedule a callMore From: Toxicon : official journal of the International Society on Toxinology
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