Abstract
The second messenger cGMP has been largely studied as a therapeutic target in a variety of disorders such as erectile dysfunction, arterial hypertension and heart failure. Evidence has shown thatcGMP activators are less efficient in estrogen-deficiency animals, but no studies exist involving non-pharmacological approacheson NO/cGMP signaling pathway in hypertensive postmenopausal women. The aim of this study is to examine NO/cGMP pathway, redox state and blood pressure in trained treatedhypertensive (HT) postmenopausal women comparing with normotensive (NT) group. The rationale for that is most of HT patients is encouraged by physician to perform exercise associated with pharmacological treatments.Aerobic exercise training (AET) consisted of 24 sessions, 3 times/week.Parameters were evaluated at baseline and after AET for both groups (HT=28; NT=33).In treatedHT group, AET was significantly effective in increasing cGMP concentrations (28%) accompanied by an up-regulation of SOD (97%) and catalase activity (37%). In NT group, we found an increasein SOD activity (58%). TreatedHT postmenopausal women were still responsive to AET increasing cGMP levels and up-regulating antioxidant system. It should also be emphasized that these findings provide information on the circulating biomarkers that might delay the developing of cardiovascular events in this particular population.
Highlights
The second messenger cyclic guanosine 3’5’monophosphate has been largely studied as a therapeutic target in a variety of disorders such as erectile dysfunction, arterial hypertension, atherosclerosis and heart failure
It has been shown that aerobic exercise training (AET) is an important approach to prevent or to mitigate the complications of cardiovascular diseases (CVD) promoting an improvement of eNOS/nitric oxide (NO) signaling pathway in both humans and laboratory animals[4,5]
The objective of this study was to examine the effects of Aerobic exercise training (AET) on cyclic guanosine 3’5’monophosphate (cGMP) levels in hypertensive postmenopausal women treated with antihypertensive therapy
Summary
The second messenger cyclic guanosine 3’5’monophosphate (cGMP) has been largely studied as a therapeutic target in a variety of disorders such as erectile dysfunction, arterial hypertension, atherosclerosis and heart failure. It has been shown that aerobic exercise training (AET) is an important approach to prevent or to mitigate the complications of CVD promoting an improvement of eNOS/NO signaling pathway in both humans and laboratory animals[4,5]. Only two studies exist evaluating the effects of AET on cGMP levels in women after menopause; the number of the participants were too small and no age-matched group was studied[6,7]. The objective of this study was to examine the effects of AET on cGMP levels in hypertensive postmenopausal women treated with antihypertensive therapy. We compared treated hypertensive postmenopausal women with normotensive and the effects of AET on blood pressure and its association with cardiovascular biomarkers
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