Abstract
ObjectiveThis study was undertaken to determine whether advanced maternal age has an impact on survival among quadruplets and quintuplets. Study designA retrospective cohort study was performed on 1 448 quadruplets and 180 quintuplets delivered in the United States between 1995 and 1997. Infants of older mothers (≥35 years old) were compared with those of younger ones (<35 years old) in terms of early mortality indices. Adjusted mortality probabilities were computed by yearly intervals of maternal age. ResultsThe likelihood for neonatal (odds ratio [OR]=2.00, 95% CI=1.20-3.45), perinatal (OR=2.10, 95% CI=1.32-3.23), and infant mortality (OR=2.13, 95% CI=1.28-3.60) was significantly higher among younger mothers. For each unit decrease in maternal age, the odds of stillbirth, neonatal, perinatal, and infant death went up by 9%, 12%, 13%, and 12%, respectively, in a dose-dependent fashion (P for trend <.0001). ConclusionWe found increasing maternal age to be associated with favorable survival outcomes among quadruplets and quintuplets.
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