Abstract
The influence of Adriamycin (doxorubicin) on the rate of superoxide radical formation in isolated rat heart mitochondria was studied by EPR with the Tiron spin trap not penetrating the mitochondrial inner membrane. Adriamycin at 10–150 μM considerably enhanced superoxide generation in the presence of succinate (substrate of the respiratory chain complex II) and glutamate/malate (complex I substrate) when electron transfer was blocked in complex III with antimycin A. Such effects may partly account for the known cardiotoxicity of this antitumor drug.
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