Abstract
The effects of ACTH on cyclic AMP levels in peripheral and adrenal vein plasma as well as in adrenal tissue were studied in the hypophysectomized rat and correlated with the steroidogenic response. High doses of ACTH increased adrenal tissue cyclic AMP levels and also markedly elevated cyclic AMP in adrenal vein and peripheral plasma. The gradient between adrenal vein and peripheral plasma cyclic AMP following ACTH was comparable to that observed for corticosterone. Small doses of ACTH produced a maximal rate of steroidogenesis and a several fold elevation in adrenal tissue cyclic AMP, but produced only a slight change in adrenal vein plasma cyclic AMP and no detectable change in peripheral plasma cyclic AMP. The present study indicates that although the adrenal cortex can extrude cyclic AMP in response to ACTH, the gland probably contributes minimally to the extracellular cyclic AMP pool in rats under physiological conditions. (Endocrinology 92: 1502, 1973)
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