Abstract

The effect of adrenocortical steroids on the urinary and fecal excretion of calcium was studied in 2 cases of Wilson's disease: one patient had hypercalciuria; the other did not. Both patients had an increase in urinary excretion and a decrease in fecal excretion of calcium while receiving orally 45 mg. of prednisone a day. The patient without hypercalciuria later exhibited similar changes when given orally 45 mg. of cortisone acetate a day. Although these findings shed no light on the cause of hypercalciuria seen in some cases of Wilson's disease, they do show that the urinary excretion of calcium by patients with Wilson's disease can be altered by the administration of adrenocortical steroids.

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