Abstract
Abstract We studied ADP-ribosylation in the vegetative life cycle of the myxomycete Physarum polycephalum. Proliferating macroplasmodia are delayed in their progression through the cell cycle by the specific ADP-ribo-syltransferase inhibitor 3-methoxybenzamide. DNA and RNA synthesis is depressed. During the differentiation of microplasmodia into quiescent microsclerotia, ADP-ribosylation strongly increases in an early stage. The same stage is sensitive towards treatment with 3-methoxybenzamide, which delays the termination of the sclerotization process. The increase of ADP-ribosylation is not evenly distributed among all nuclear acceptor proteins. Histones H3 and H4 are modified to a lower extent in relation to H2A and H2B at the time of maximum ADP-ribosylation. Germination of microsclerotia into growing plasmodia is also repressed by 3-methoxybenzamide.
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