Abstract
Administration of sodium aurothiomalate (SATM) to adult mice results in a reduction of their average survival time (AST) following intracerebral challenge with the wild-type strains, Asibi and French viscerotropic virus (FVV), of yellow fever (YF) virus. Most attenuated 17D YF vaccines, derived by passage of the wild-type Asibi strain in chick tissue, showed no reduction in AST following intracerebral challenge and administration of SATM. In contrast, challenge with the majority of live attenuated French neurotropic vaccines, derived by passage of FVV in mouse brain, still resulted in SATM reducing the AST of mice. SATM also changed some YF viruses from non-lethal to lethal following intraperitoneal challenge and negated the ability of a monoclonal antibody to elicit passive protection of mice challenged intracerebrally with YF virus.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
