Abstract
754 Background: To evaluate the effect of adjuvant tamoxifen (TAM) and letrozol (LETR) on the occult peripheral blood (PB) CK-19 mRNA+ cells in correlation with the clinical outcome. Methods: Patients were treated with TAM (group TAM: n= 117 pts), LETR (LETR: n= 34pts) or sequential TAM (2 or 3 years) and LETR (3 or 2 years) (TAM/LETR: n= 46pts) after completion of adjuvant chemotherapy. CK-19 mRNA+ cells were detected by real-time RT-PCR. Results: Post-chemotherapy, CK-19 mRNA+ cells could be detected in 39 (33.3%), 13 (38.2%) and 14 (30.4%) patients treated with TAM, LETR, and TAM/LETR, respectively. Hormone treatment resulted in undetectable levels of PB CK-19 mRNA+ cells in 33 (84.5%) TAM and 11 (85%) LETR patients. In the TAM/LETR group, LETR resulted in undetectable levels of CK-19 mRNA+ cells in 12 (80%) of 15 patients with CK-19 mRNA+ cells after adjuvant TAM. The median duration of CK-19 mRNA-negative peripheral blood was higher in patients receiving LETR (LETR and TAM/LETR groups) than in those ...
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