Effect of adenosine deaminase activity on lipid profile in patients of type 2 diabetes mellitus

Abstract

Background: Type 2 diabetes mellitus is a worldwide endemic disease. Dyslipidemia is also a frequent disorder associated with diabetic patients. The present study is an attempt to link that elevated levels of adenosine deaminase in Type 2 diabetes mellitus patients augment hyperlipidemia. Material and Methods: The subjects included in this study were divided into 3 groups. Group A consisted of 30 normal healthy individuals who served as controls with no history of DM. Group B consisted of 30 patients of Type 2 Diabetes Mellitus both males & females in the age group of 40-65 years on oral hypoglycaemic drugs with HbA1c 7 %. Serum levels of fasting blood sugar, HbA1c, ADA and lipid profile were estimated in all the subjects under study. Results: All the three parameters, FBS, HbA1c and ADA levels were found to be increased in the patients of Type 2 DM as compared to controls. The mean S. Triglyceride and S. VLDL-C levels were significantly elevated in group C as compared to Group A. The mean serum levels of S. HDL-C showed a decreasing trend with increase in levels of HbA1c. Conclusion: From the present study, it was concluded that dyslipidemia was found to be higher in diabetic patients with respect to healthy controls. The lipid abnormality (dyslipidemia) associated with type 2 diabetes typically consists of elevated triglyceride and decreased HDL-C levels. Keywords: Diabetes Mellitus type 2, Adenosine deaminase (ADA), Glycated haemoglobin (HbA1c), Fasting blood Sugar (FBS)