Abstract
Effect of Adding Midazolam to Bupivacaine 0.5% in Spinal Anesthesia on Middle Cerebral Artery Blood Flow in Patients with Pre-eclampsia
Highlights
Preeclampsia is a clinical syndrome defined as the new onset of hypertension and proteinuria during the second half of pregnancy
In severe preeclampsia, elevated cerebral perfusion pressure is counterbalanced by increases in cerebrovascular resistance and cerebral blood flow is unaffected(3)
Aim of the work The main target of the current research is: to exploit the GABA mimetic and potentiating effect of intrathecal midazolam to ameliorate the glutamate mediated preecmlapsia induced neuronal excitotoxicity and cerebro-vasculer vasospasm assessed by blood flow vascular indices in maternal MCA in case of sever preeclampsia
Summary
Preeclampsia is a clinical syndrome defined as the new onset of hypertension and proteinuria during the second half of pregnancy. Increased uterine arterial resistance induces higher sensitivity to vasoconstriction and chronic placental ischemia and oxidative stress. These abnormalities are responsible for endothelial dysfunction with vascular hyperpermeability, thrombophilia, and hypertension, so as to compensate for the decreased flow in the uterine arteries due to Effect of Adding Midazolam to Bupivacaine 0.5%
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