Abstract

Dental products containing calcium phosphate and fluoride are claimed to enhance enamel remineralization over fluoride products. ObjectivesTo compare remineralization of enamel subsurface lesions by dental products with added calcium phosphate in a double-blind, randomized, cross-over in situ study. MethodsHuman enamel specimens with subsurface lesions were prepared and inserted into intra-oral appliances worn by volunteers. A slurry (1g product plus 4ml H2O) of each product was rinsed for 60s, 4 times per day for 10 days. Six products were tested (i) placebo, (ii) 1000ppm F, (iii) 5000ppm F, (iv) Tooth Mousse (TM), (v) TM plus 900ppm F (TMP) and (vi) Clinpro with 950ppm F. Calcium, inorganic phosphate and fluoride levels were measured in post-rinse/saliva samples using ion chromatography. Mineral content was measured using transverse microradiography. ResultsOnly TM and TMP significantly increased salivary calcium and phosphate levels. The products produced remineralization in the following order from lowest to highest: placebo<1000ppm F=Clinpro<5000ppm F<TM<TMP. ConclusionClinpro was not significantly different to 1000ppm F whereas TM and TMP were superior to 5000ppm F with TMP producing the highest level of enamel lesion remineralization.

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