Abstract
Interactions of two adamantyl molecules: 3-(adamantan-1-yl)propan-1-aminium chloride (compound A) and 1-hydroxyadamantan (compound B) with multilayer liposomes composed of L-α-phosphatidylcholine, cholesterol and dicetylphosphate, spin labelled with n-doxylstearic acids (n = 5, 7, 10, 12, 16) were investigated. In the presence of aminium salt (A) or alcohol (B) the increased dynamics of 5-doxylstearic acids and 16-doxylstearic acids in the multilamellar liposomes were determined in the temperature range from 250 K to 295 K. The increased dynamics of 5-doxylstearic acids suggested that both adamantyl compounds influenced molecular motions in the interfacial region of the liposome. The increased motional properties of 16-doxylstearic acids, located in the core of the multilamellar liposomes, suggested that both adamantyl compounds induced the structural changes in the hydrophobic core as well.
Highlights
Multidimensional value of adamantyl group in the drug design has been pointed out in the several recent review papers.[1]
In order to be close to the cell surface polarity the negatively charged multilamelar liposomes composed of egg-phosphatidylcholine, cholesterol and dicethylphosphate, spin labelled with n-doxylstearic acids (n = 5, 10, 16) were used
The results demonstrated preference for the interfacial region of the bilayer for both protonated as well as neutral forms, while permeant species were only the small number of the neutral forms of all the three adamantanes
Summary
Multidimensional value of adamantyl group in the drug design has been pointed out in the several recent review papers.[1]. In order to get more information on the possible role of the adamantyl moiety in interactions with the liposomes that contain cholesterol and negative charge, two different types of adamantyl molecules: 3-(adamantan-1-yl)propan-1-aminium chloride (Figure 1, A) and 1-hydroxyadamantan (Figure 1, B) were studied in this work.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
