Abstract
Comparative effect of chronic administration of chloroquine phosphate and methanol extract of Landolphia owariensis on the activities of rat EnzymesIlesanmi F F, Balogun E A, Ilesanmi O S
Highlights
Kidney transplantation is the preferred method of treatment of end-stage renal disease, which significantly improves the quality of life, and increases survival when compared to dialysis
This study aimed to investigate the bad side effect of acute and chronic treatment with cyclosporin A on liver and kidneys by measuring liver enzymes and kidney function tests in serum
The data recorded in table (1) indicate a marked increase in blood urea (18.76%), which was significantly different from control level after two weeks of treatment with Cyclosporine A (CsA), whereas blood urea level underwent a highly significant increase (54.15%) in animal group treated for 4 weeks (P < 0.01)
Summary
Kidney transplantation is the preferred method of treatment of end-stage renal disease, which significantly improves the quality of life, and increases survival when compared to dialysis. Prevention of acute or chronic rejection demands the use of immunosuppressant. Nephrotoxicity, hepatotoxicity, cardiovascular disease, post-transplantation diabetes mellitus, chronic graft dysfunction and dyslipidemia may all occur as complications of immune-suppressive therapy (Ivandic and Basic-Jukic, 2014). Cyclosporine A (CsA), a cyclic undecapeptide, which is one of the major immunosuppressants, has been used for the prevention of life-threatening transplant rejection responses as well as the treatment of immune diseases. CsA has played an important role in the development of organ transplants, its clinical use has been severely limited due to the nephrotoxicity of CsA, a common and serious side effect (Farh, 1993). CsA is metabolized by the cytochrome p-450, a CYP3A4 isoform, in the liver
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