Abstract
BackgroundAllergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated inflammatory response.Persistent allergic rhinitis (PAR) is a subtype of AR, but the treatment of PAR is still a problem. Acupuncture is used as an alternative therapy for AR in clinical practice. The aim of this study is to evaluate the effectiveness of acupuncture therapy combined with fluticasone propionate nasal spray in comparison to fluticasone propionate nasal spray alone in the relief of symptoms for PAR.MethodsThis study is a multicenter, single-blind, randomized controlled trial. A total of 260 eligible patients will be randomly assigned into the treatment group or the control group. The treatment group will receive the nasal fluticasone propionate combined with acupuncture, and the control group will receive fluticasone propionate nasal spray alone for 6 weeks. The primary outcome is the change in the Reflective Total Nasal Symptom Score (rTNSS) from baseline to the end of treatment, and the Total Non Nasal Symptom Score (TNNSS), reflective total ocular symptom score (rTOSS), Rhinitis Quality of Life Questionnaire (RQLQ), use of antiallergic drugs, and the Rhinitis Control Assessment Test (RCAT) are used as secondary outcomes. The participants will be followed up for another 24 weeks after treatment.DiscussionThis clinical trial will be able to provide high level evidence on the acupuncture therapy combined with fluticasone propionate nasal spray in the treatment of PAR.Trial registrationISRCTN Registry, ID: ISRCTN44040506. Registered on 22 July 2020.
Highlights
Background and rationale {6a} Allergic rhinitis (AR) is defined as a symptomatic disorder of the nose resulting from an immunoglobulin E (IgE)-mediated immunological reaction to allergen exposure [1]
Objectives {7} This study aims to evaluate the efficacy of acupuncture therapy combined with fluticasone propionate nasal spray in patients with moderate to severe Persistent allergic rhinitis (PAR)
Our pilot research showed that the change in Reflective Total Nasal Symptom Score (rTNSS) of acupuncture therapy combination with fluticasone was 5.33 ± 3.96
Summary
Background and rationale {6a} Allergic rhinitis (AR) is defined as a symptomatic disorder of the nose resulting from an immunoglobulin E (IgE)-mediated immunological reaction to allergen exposure [1]. This highly prevalent inflammatory respiratory disease affects approximately 10–25% of the global population [2]. Clinicians may offer combination therapy in patients with persistent symptoms [7, 12].
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