Abstract
Experiments on 5- and 10-month-old rats demonstrate a protective effect of active preimmunization with serotonin-protein conjugate on the development and course of the parkinsonismlike syndrome induced by intranigral injection of 1-methyl-4-phenylpyridinium+. The protective effect of antiserotonin antibodies was more pronounced in younger animals. The severity of manifestations of the syndrome may depend on the level of antidopamine autoantibodies.
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