Abstract
Actinomycin D, in vivo, in mice markedly reduces the sodium, potassium and iodide ion excretion indicating an impaired renal clearance. Histopathological examination of kidney of mice injected with the drug reveal distinct degenerative changes in the distal tubule region. The degree of damage to the kidney parallels the amount of the drug injected. The rates of the emptying time of iodide from the stomach to the intestine and excretion through the kidney are significantly lowered in the experimental animals. The increased thyroidal radioiodine uptake after 5 hr is due to a longer availability of the radioiodine caused by the impaired renal clearance and a delay in emptying time of stomach. Histological findings do not show any evidence of stimulation of thyroid gland.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
