Abstract
Effects of ACTH on the corticosteroid production and the adenyl cyclase activity of the zona fasciculata and reticularis (the decapsulated gland) and the zona glomerulosa (the capsular gland) of the rat adrenal glands incubated in separate vessels have been studied. The adenyl cyclase activity in both preparations was assayed by estimating the radioactivity of adenosine 3′,5′-cyclic monophosphate (CAMP) formed from labeled adenosine triphosphate (ATP). The decapsulated gland incubated in the presence of ACTH was observed to produce more corticoids than the capsular, while the adenyl cyclase activity in both glands was increased to the same extent. These results lead to the question of whether or not all the CAMP induced by ACTH participates in the regulation of the rate of corticoid production in both the decapsulated and the capsular gland. (Endocrinology 88: 465, 1971)
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