Abstract
Background Acid-sensing ion channels (ASICs) belong to the amiloride-sensitive epithelial Na+ channels/degenerin (ENaC/DEG) superfamily.These channels are widely expressed in the peripheral and central nervous systems.Recent studies have demonstrated that the activation of ASIC1a is largely responsible for acidosis-mediated,glutamate independent ischemic neuronal injury.Objective To overview the effect of ASICs on ischemic brain injury.Content This review focuses on the structure,distribution and function of ASICs as well as its role in ischemic brain injury.Trend ASICs may help to explain the mechanism underlying ischemic brain injury,and may also provide the directions and ideas for clinical treatment of ischemic brain injury. Key words: Acid-sensing ion channel; Ischemia brain injury; Acidosis; Calcium
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