Abstract
1. Acetylsalicylic acid (ASA; 400 mg/kg, IP) increased serotonin (5-HT) content in rat brain but did not modify the number or the affinity of 5-HT 1A receptors in the pons and the cerebral cortex, whereas the number of cortical 5-HT 2 receptors decreased significantly. 2. Pretreatment with parachlorophenylaline (100 mg/kg/day for 4 days) depleted 5-HT brain content but modified neither the serum levels of salicylates nor the 5-HT 2 cortical receptor characteristics, and it abolished the antinociceptive effect of ASA, 400 mg/kg, in the first phase of the formalin test. 3. These data support the involvement of the central serotonergic system in the antinociceptive activity of ASA.
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