Abstract
In the isolated rabbit ear artery, low concentrations of exogenous acetylcholine inhibited the response of the artery to periarterial electrical stimulation, while much greater concentrations of acetylcholine were required to inhibit the response to exogenous noradrenaline. This action of acetylcholine on periarterial stimulation was suppressed by atropine and potentiated by cholinesterase inhibitors. Neither atropine nor cholinesterase inhibitors, in concentrations which modified the effects of exogenous acetylcholine, altered the response of the artery to periarterial stimulation. The study failed to confirm that either a cholinergic element or endogenous acetylcholine has an effect in the arterial sympathetic nerve response.
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