Abstract
BackgroundNumerous studies have demonstrated that patients with non-O blood groups have a higher risk for venous thromboembolism than those with the O blood group. However, the effect of ABO blood groups on warfarin dose requirements in patients receiving anticoagulation in the Chinese Han population remains unknown. This study aimed to investigate the influence of ABO blood groups on warfarin dose requirements in a Chinese Han population. Material and MethodsA retrospective study was conducted in the First Affiliated Hospital of Shantou University Medical College in South China. Three hundred and fifty-eight patients with a confirmed diagnosis of deep vein thrombosis or atrial fibrillation were included. The frequency of blood groups and warfarin dose requirements were determined. ResultsOf 358 patients with deep vein thrombosis or atrial fibrillation, 111 patients had blood group A (31.01%), 104 patients had blood group B (29.05%), 20 patients had blood group AB (5.59%) and 123 patients had blood group O (34.36%). The patients in the O blood group had lower warfarin dose requirements than those in the A, B and AB blood groups. ConclusionsOur study showed that patients with non-O blood groups require higher doses of warfarin.
Highlights
Numerous studies have demonstrated that patients with non-O blood groups have higher risk for venous thromboembolism than those with O blood group
In present study we aimed to investigate the influence of ABO blood groups on warfarin dose requirements in patients with deep vein thrombosis (DVT) and atrial fibrillation (AF) in Chaoshan District of Guangdong Province in South China
There are no differences of warfarin dose requirements among A, B and AB blood group
Summary
Numerous studies have demonstrated that patients with non-O blood groups have higher risk for venous thromboembolism than those with O blood group. It has remained unknown about the effect of ABO blood groups on warfarin dose requirements in patients receiving anticoagulation in Chinese Han population. The study aimed to investigate the influence of ABO blood groups on warfarin dose requirements in Chinese Han population. Warfarin is the most commonly prescribed oral anticoagulant drug since 1950s [1], which has been widely used to prevent embolic stroke in patients with atrial fibrillation (AF) [2] and treatment of thromboembolic disorders. The anticoagulant activity of warfarin is assessed by using the International Normalised Ratio (INR) [4]. It is important to identify the clinical and genetic predictors of warfarin dose-response in individual patients [5,6,7]
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