Abstract
Abnormal Balgham Munziq (ABMq) is a traditional Uighur medicie herbal preparation commonly used to preventing and treating the vitiligo. To study the mechanism of this preparation its effect on the activity of mushroom tyrosinase, the melanogenesis and proliferation of B16 murine melanoma cell were estimated using non-cell vitro system as well as in culture. The results showed that at concentration of 0.5–200µg, aqueous extracts and ethanol extracts of ABMq significantly activate the mushroom tyrosinase, melanogenesis in the non cells system in vitro. The ethanol extracts strongly activate the tyrosinase activity and increase melanogenesis than aqueous extracts, also show dosage depend manner. The aqueous extracts and ethanol Isolation from ABMq also has a strong potential to promote the proliferation and melanogenesis of B16 cell, also can promote cell tyrosinase activity. The results of the present study suggest that the putative mechanisms of ASMq in treatment vitiligo may at least involve enhance the proliferation of melanocyte, melanogenesis, the tyrosinase activity of melanocyte. This activity may play an important role in its treatment of vitiligo.
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