Abstract
The hexapeptide dalargin (a synthetic analog of leu-enkephalin) injected in the hemolymph of bee moth (Galleria mellonella) and of mealworm (Tenebrio molitor) causes a dose-dependent increase in the DNA content and an increase in the3H-thymidine incorporation in DNA. In bee moth, the maximum (43–68%) increase in radioactivity is observed after injection of 10−8 to 10−10 M of dalargin per insect, in mealworm, the highest radioactivity of DNA (73 and 162% increase) is recorded after 10−11 and 10−9 M dalargin per insect. Dalargin modifies the nucleic acid metabolism in the insects, which manifests itself as accumulation of extra DNA and enhanced DNA biosynthesis.
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