Abstract
A propionylated derivative of glucosamine (likely N-propionyl glucosamine) was prepared from propionic anhydride based on the method of preparation of N-acetyl glucosamine from acetic anhydride. This derivative inhibited, in vitro, the incorporation of labelled glucosamine or glucose into mucopolysaccharides (MPS) synthesized by human joint capsule and synovial tissue. The effect was similar to that observed when the anti-inflammatory agents, hydrocortisone or acetylsalicylic acid, were added to the system in vitro. These agents affect MPS synthesis through complex mechanisms. However, the inhibition by propionyl glucosamine appeared to be due to a specific effect on the incorporation of hexosamine precursors which could not be simply accounted for by pool dilution of the radioactivity.
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