Abstract
The cytochrome P-450 1A1 induction response following TCDD exposure has been characterized in liver; however little is known regarding extrahepatic targets of TCDD. This study was designed to compare the 1A1 induction response of hepatic to extrahepatic tissue after oral TCDD exposure. 1A1 was induced in all tissues, with liver, lung and kidney exhibiting an early maximum and subsequent gradual decrease over 4 weeks, and intestines demonstrating a rapid loss of enzyme activity over time. The magnitude of induction was significantly greater in liver and lung following oral vs. intraperitoneal administration. These studies suggest differences in 1A1 induction in hepatic vs. extrahepatic tissue and with different routes of administration.
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