Effect of a single insulin administration on the hepatic release of triglycerides into the plasma

Abstract

The acute effect of insulin on the hepatic release of triglycerides in the tritonized fasting rat was studied using [ 3H]palmitate as precursor. Insulin did not influence the uptake nor the esterification of the label under these conditions. Insulin modified the kinetic release of newly synthesized triglycerides. The net secretion of triglycerides decreased under the influence of the hormone, leading to a minimal input in the plasma of triglycerides with a high specific radioactivity. The effect of insulin under these conditions is interpreted as a decrease of fatty acid flow, coming from the hydrolysis of the reserve triglyceride pool toward the synthesis of triglycerides for export to plasma.