Abstract
The kynurenine (KYN) pathway gains growing research interest concerning the genesis, progression and therapy of solid tumors. Previous studies showed exercise-induced effects on metabolite levels along the KYN pathway. Modulations of the KYN pathway might be involved in the positive impact of exercise on prostate cancer progression and mortality. The objective of this trial was to investigate whether a single-physical exercise alters tryptophan (TRP) metabolism and related inflammatory markers in this population. We conducted a randomized controlled trial with 24 patients suffering from prostate cancer. While the control group remained inactive, the intervention group performed a 30-min aerobic exercise on a bicycle ergometer at 75% of individual VO2peak. Before (t0) and directly after the exercise intervention (t1) KYN, TRP, kynurenic acid, quinolinic acid as well as various inflammation markers (IL6, TNF-α, TGF-β) were measured in blood serum. At baseline, the present sample showed robust correlations between TRP, KYN, quinolinic acid and inflammatory markers. Regarding the exercise intervention, interaction effects for TRP, the KYN/TRP ratio and TGF-β were observed. The results show for the first time that acute physical exercise impacts TRP metabolism in prostate cancer patients. Moreover, baseline associations underline the relationship between inflammation and the KYN pathway in prostate cancer.
Highlights
Prostate cancer, as the second most diagnosed malignancy in men, represents the fifth leading cause of death worldwide [1]
The results show for the first time that acute physical exercise impacts TRP metabolism in prostate cancer patients
Exercise has been identified as a modulator of the KYN-pathway. In both healthy and multiple sclerosis patients, it has been shown that an acute of aerobic exercise leads to an increased TRP metabolism via the KYN pathway [38,39]
Summary
As the second most diagnosed malignancy in men, represents the fifth leading cause of death worldwide [1]. In both healthy and multiple sclerosis patients, it has been shown that an acute (single bout) of aerobic exercise leads to an increased TRP metabolism via the KYN pathway [38,39] This could provide an explanation for the positive effects of physical activity on the development and progression of miscellaneous diseases. According to our current state of knowledge, there is no study investigating the influence of a single bout or chronic physical exercise on the KYN pathway in prostate cancer patients. The aim of this pilot randomized controlled trial was to investigate whether a single bout of aerobic exercise impacts KYN pathway metabolite levels and related inflammatory markers in prostate cancer patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
