Abstract

Hippocampal lesioned and sham operated rats were required to relearn entry into a previously learned reinforced side arm in a T-maze from a new starting position 180 degrees from the original location. Half of each operated group were allowed free access while the other half had to open clear plastic doors to gain entry into the side arms. Only those hippocampal lesioned rats allowed free access to the side arms failed to relearn the entry response in fewer errors or with significant slower running speed than in the initial task. Both sham operated subgroups and the obstructed hippocampal lesioned group of rats learned the second task in fewer errors and displayed running speed disruption. The results were discussed in terms of a deficit of internal inhibition due to the limbic damage.

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