Effect of a patient education and rehabilitation program on anxiety, depression and quality of life in muscle invasive bladder cancer patients treated with adjuvant chemotherapy.

Zhonghui Li,Qing Zhang,Chenxi Zhu,Dan Wei

doi:10.1097/md.0000000000017437

Zhonghui Li, Qing Zhang + Show 2 more

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https://doi.org/10.1097/md.0000000000017437

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Journal: Medicine	Publication Date: Nov 1, 2019
Citations: 15	License type: CC BY 4.0

Affiliation: Central Hospital of Wuhan

Abstract

This study aimed to investigate the effect of a patient education and rehabilitation program (PERP) on anxiety, depression, and quality of life in muscle invasive bladder cancer (MIBC) patients underwent adjuvant chemotherapy.One hundred and thirty MIBC patients about to receive adjuvant chemotherapy with 4-cycle gemcitabine and cisplatin (GC) regimen (16 weeks) were consecutively enrolled and randomly allocated into PERP group and control group as 1:1 ratio. Hospital Anxiety and Depression Scale (HADS) anxiety and depression scores and Quality of Life Questionnaire (QLQ-C30) scores were assessed before treatment (W0) and after treatment (W16).After 16-week treatment, PERP group exhibited decreased HADS anxiety score (P = .036), ΔHADS anxiety score (W16-W0) (P < .001) and percentage of anxiety patients (P = .019) compared to control group. And PERP group presented with numerically reduced HADS depression score but without statistical significance (P = .076) compared to control group, while lower ΔHADS depression score (W16-W0) (P = .014) and percentage of depression patients (P = .015) compared to control group. As to quality of life, QLQ-C30 global health status score (P = .032), Δglobal health status score (W16-W0) (P = .003) and Δfunctional score (W16-W0) (P = .005) were higher in PERP group compared to control group. However, no difference of QLQ-C30 functional score (P = .103), QLQ-C30 symptom score (P = .808) or Δsymptom score (W16-W0) (P = .680) was observed between two groups.PERP relieves anxiety, depression and improves quality of life in MIBC patients underwent adjuvant chemotherapy.

Highlights

Bladder cancer is one of the top 10 commonly diagnosed malignancies in China
Effect of a patient education and rehabilitation program on anxiety, depression and quality of life in muscle invasive bladder cancer patients treated with adjuvant chemotherapy
65 patients were randomly assigned to the patient education and rehabilitation program (PERP) group, and 65 patients were randomly allocated to the control group

Summary

Introduction

Bladder cancer is one of the top 10 commonly diagnosed malignancies in China. According to the 2015 cancer statistics, there are 8,05,000 new cases and 3,29,000 deaths by it annuallyEditor: Jianxun Ding.ZL and DW contributed to this work.The authors declare that they have no conflict of interest. a Department of Urology Surgery, b Department of Thoracic Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China. ∗How to cite this article: Li Z, Wei D, Zhu C, Zhang Q. Bladder cancer is one of the top 10 commonly diagnosed malignancies in China. According to the 2015 cancer statistics, there are 8,05,000 new cases and 3,29,000 deaths by it annually. ZL and DW contributed to this work. The authors declare that they have no conflict of interest. A Department of Urology Surgery, b Department of Thoracic Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China. ∗. How to cite this article: Li Z, Wei D, Zhu C, Zhang Q. Effect of a patient education and rehabilitation program on anxiety, depression and quality of life in muscle invasive bladder cancer patients treated with adjuvant chemotherapy.

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