Abstract
This study was included prepare a cold aqueous extract of solanaceae fruit plant. The study also comprised the isolation and study the proteinaceous compounds, seperated by using the gel filtration technique which was isolated two compound A (52251) Dalton and B (6725) Dalton . The effects of these extracts and compounds previously mentioned above were studied on serum glucose , total cholesterol , triglyceride (TG) , low density lipoprotein-cholesterol ( LDL-C ) and high density lipoprotein-cholesterol ( HDL-C ) levels , also glutathione ( GSH ) and malondialdehyde ( MDA ) levels in liver, kidney and heart tissues in diabetic mice- induced alloxan. Extracts were administerated interaperitioneally. After one week from the treatment the results were indicated that the crude aqueous non proteinaceous extract , proteinaceous precipitate and proteinaceous compounds ( A ) and ( B ) which were caused a significat decrease in serum glucose, total cholesterol , TG, LDL-C leves and MDA level in liver , kidney and heart tissues , with an associated significant increase in serum HDL-C level and GSH level in liver , kidney and heart tissues , in alloxan-induced diabetic mice. finally we suggest that most of extracts isolated from fruit plant ( especially compound B ) have anti-diabetic effect in diabetic mice.
Highlights
This study was included prepare a cold aqueous extract of solanaceae fruit plant
After one week from the treatment the results were indicated that the crude aqueous non proteinaceous extract, proteinaceous precipitate and proteinaceous compounds ( A ) and ( B ) which were caused a significat decrease in serum glucose, total cholesterol, TG, LDL-C leves and MDA level in liver, kidney and heart tissues, with an associated significant increase in serum HDL-C level and GSH level in liver, kidney and heart tissues, in alloxan-induced diabetic mice. finally we suggest that most of extracts isolated from fruit plant ( especially compound B ) have antidiabetic effect in diabetic mice
(27لقد أدى حقن الأنسولين إلى انخفاض مستوى المالوندايالدييايد في الأنسجة المدروسة وىذا يتفق مع نتائج د ارسة عزيز ) ,(28وربما يعزى السبب إلى ارتفاع مستويات مضادات الأكسدة بعد المعاممة بالأنسولين ).(29كما أدى حقن المستخمصات المذكورة أنفا إلى انخفاض معنوي في مستوى المالوندايالدييايد ,ماعدا المستخمص المائي الخام وال ارسب البروتيني
Summary
This study was included prepare a cold aqueous extract of solanaceae fruit plant. The study comprised the isolation and study the proteinaceous compounds, seperated by using the gel filtration technique which was isolated two compound A (52251) Dalton and B (6725) Dalton.
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