Abstract
ABSTRACT The potent sulfhydryl (SH) inhibitor iodoacetic acid (IAA) has previously been found to be non-diabetogenic in the marine teleost Cottus scorpius (the daddy sculpin). It was administered as a single intramuscular injection at approximately the L. D. 50 and also at a sublethal dose. The glutathione (GSH) content in the isolated islet tissue was significantly lowered to approximately the same extent with both doses. The GSH decrease differed from that obtained after administration of the diabetogenic SH inhibitor alloxan. It appeared later and lasted longer. Moreover, there was no clear difference between the GSH lowering effect of IAA on the isolated islet tissue and of that on some organs such as the myocardium not believed to be involved in the pathogenesis of diabetes mellitus.
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