Abstract
Summary:The intravenous infusion of a phosphatidyl serine fraction into pigs or dogs caused prolonged bleeding from transected vessels. This effect appeared to be due to inhibition of blood coagulation and of platelet aggregation induced both by collagen and by thrombin. This influence on the effect of thrombin and collagen on platelets may be attributed to suppression of the release of platelet constituents, including ADP, for the phosphatidyl serine fraction does not inhibit ADP‐induced aggregation.
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