Abstract
BackgroundWe aimed to evaluate clinically the effect of mouthrinse containing a rice peptide on early dental plaque regrowth.MethodsThe study was designed as a double-masked, two-group crossover randomized pilot trial, involving 10 periodontally healthy volunteers. After receiving a professional tooth cleaning at baseline, over the next 3 days each participant refrained from all oral hygiene measures and had two daily rinses with 20 ml of the test mouthrinse containing 0.4 % rice peptide CL(14-25) or placebo rinse. At the end of each experimental period, plaque score was assessed using the modified Volpe’s method, and the participants filled out a questionnaire. Each participant underwent a 7-day washout period followed by a second allocation. The plaque score was the primary outcome of the study and participant perception was the secondary outcome.ResultsNo adverse effects were observed in the participants during the study. Clinically, the mean plaque score of the examined teeth was significantly lower in the test group (2.44 ± 0.74, CI: 1.91–2.96) than the placebo group (2.65 ± 0.63, CI: 2.20–3.10) (P < 0.05). When analyzed according to the type of teeth, a significantly lower score of the premolars/molars was observed in the test group (2.39 ± 0.68, CI: 2.08–2.71) than that in the placebo group (2.66 ± 0.58, CI: 2.39–2.93) (P < 0.05).ConclusionsThe mouthrinse containing 0.4 % rice peptide CL(14-25) was effective in reducing the early regrowth of dental plaque. However, clinical relevance of this efficacy needs to be validated in a future large-scale study.Trial registration: UMIN Clinical Trials Registry (UMIN-CTR) R000014000. Date of formal registration: November 1, 2013.
Highlights
We aimed to evaluate clinically the effect of mouthrinse containing a rice peptide on early dental plaque regrowth
In order to control plaque biofilms, numerous antiplaque and antimicrobial agents have been formulated into toothpastes and mouthrinses [2,3,4,5]
Evidence providing the effectiveness of natural compounds containing mouthrinse as an adjunct to unsupervised oral hygiene for the control of dental plaque is still insufficient [25]
Summary
We aimed to evaluate clinically the effect of mouthrinse containing a rice peptide on early dental plaque regrowth. In order to control plaque biofilms, numerous antiplaque and antimicrobial agents have been formulated into toothpastes and mouthrinses [2,3,4,5]. The efficacy of those agents used in adjunct to mechanical plaque control has been demonstrated in many studies [6,7,8]. The antimicrobial agents could disrupt the natural microbial ecology of the mouth, which might result in overgrowth of opportunistic or resistant pathogens [2]. An antimicrobial agent should not induce drugresistance or disrupt the oral microbial ecology
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