Effect of a hypolipidaemic drug (CH 13,437) on plasma and tissue lipids, and on the intravenous fat tolerance in man

Abstract

Nine patients were treated with CH 13,437 for about 1 to 2 months. Plasma cholesterol and triglycerides (TG) were on average lowered by 18 and 38%. Eight patients had elevated plasma TG and low intravenous fat tolerance values before treatment and on average the fat tolerance improved by 100 % during treatment. It was suggested that CH 13,437 lowers plasma TG by increasing their clearance from blood. Further support for this was obtained from preliminary data showing that neither turnover of plasma. TG nor turnover of plasma FFA had been lowered by the drug. Plasma lipoproteins were separated in the preparative ultracentrifuge and the content of cholesterol, phospholipids and triglycerides analysed in the three main lipoprotein classes. CH 13,347 did not change the composition of the various lipo protein classes not even when this was abnormal with an unusually high ratio cholesterol/triglycerides in the very low density lipoproteins (Type 111). On the average the very low density lipoprotein class was reduced by 50% and the low density by 15% while the high density had a tendency to increase. Lipoprotein lipase activity in plasma 5 and 40 min after heparin injection was not significantly changed during treatment. Skeletal muscle content of triglycerides, phospholipids and glycogen remained unchanged during treatment.