Effect of a high protein/low glycaemic index diet on insulin resistance in adolescents with overweight/obesity – a preview randomized clinical trial

Abstract

In brief: This randomized parallel trial, conducted in the Netherlands, the United Kingdom and Spain, assessed the impact of a high protein/low glycaemic diet vs. medium protein/medium glycaemic diet in reducing insulin resistance in 126 adolescents with overweight/obesity (mean age 13.6±2.2 years). At 2 years, no effect was shown on insulin resistance. The authors concluded that the null findings were due to infeasibility of the diet, insufficient study retention and poor dietary compliance.